Rest-Activity Rhythm, Pain, and Motor Activity in Multiple Sclerosis

ABSTRACT BACKGROUND Although the relationships among physical disability, mood disorders, and pain are well described in multiple sclerosis (MS), little is known about whether those symptoms associated with sleep disturbances. METHODS Forty-six patients MS experiencing participated. Sleep was indirectly measured by assessing rest-activity rhythm via actigraphy: interdaily stability, intradaily variability, relative amplitude. Pain assessed using visual verbal analog scales, Beck Depression Inventory Symptom Checklist-90, disability Expanded Disability Status Scale. RESULTS Incorporating mood, pain, into 1 regression model resulted a significant association stability. CONCLUSIONS Compared variability amplitude, stability seems to be most vulnerable actigraphy variable for disturbances, disabilities.